Dapoxetine hydrochloride Impurity M
(R)-(+)-3-chloro 1-phenyl-1-propanol
CAS: 100306-33-0
Molecular Formula: C9 H11 Cl O
Dapoxetine hydrochloride Impurity M - Names and Identifiers
| Name | (R)-(+)-3-chloro 1-phenyl-1-propanol |
| Synonyms | 3-chloro-1-phenylpropan-1-ol (R)-(+)-3-CHLORO-1-PHENYL-1-PR (1R)-3-Chloro-1-phenyl-propan-1-ol (R)-(+)-3-chloro 1-phenyl-1-propanol Dapoxetine hydrochloride Impurity M (R)-(+)-3-Chloro-1-phenyl-1-propanol (αR)-α-(2-Chloroethyl)benzeneMethanol R-(+)-1-chloro-3-hydroxy-3-phenylpropane Benzenemethanol, α-(2-chloroethyl)-, (αR)- (1R)-3-Chloro-1-Phenyl-Propan-1-ol (R)-(+)-3 (R)-(+)-3-CHLORO-1-PHENYLPROPANOL((R)-3-chloro-1-phenylpropan-1-ol) α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-α-(2-Chloroethyl)benzyl alcohol, (R)-(+)-3-Chloro-1-phenylpropanol |
| CAS | 100306-33-0 |
| EINECS | 627-168-3 |
| InChI | InChI=1/C9H11ClO/c10-7-6-9(11)8-4-2-1-3-5-8/h1-5,9,11H,6-7H2/t9-/m1/s1 |
| InChIKey | JZFUHAGLMZWKTF-SECBINFHSA-N |
Dapoxetine hydrochloride Impurity M - Physico-chemical Properties
| Molecular Formula | C9 H11 Cl O |
| Molar Mass | 170.64 |
| Density | 1.149±0.06 g/cm3(Predicted) |
| Melting Point | 58-60 °C (lit.) |
| Boling Point | 296.4±20.0 °C(Predicted) |
| Specific Rotation(α) | 26 º (c=1, chloroform) |
| Flash Point | 132°C |
| Solubility | Chloroform (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.000651mmHg at 25°C |
| Appearance | White crystal |
| Color | White to yellow |
| BRN | 5250766 |
| pKa | 13.92±0.20(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.543 |
| MDL | MFCD00075128 |
Dapoxetine hydrochloride Impurity M - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 - Wear suitable protective clothing. |
| WGK Germany | 3 |
| HS Code | 29062990 |
| Hazard Class | IRRITANT |
Dapoxetine hydrochloride Impurity M - Introduction
(R)-(+)-3-Chloro-1-phenyl-1-propanol, also known as (R)-(+)-α-methylphenylethanol, is a chiral organic compound. Its chemical formula is C9H11ClO and its molecular weight is 168.63g/mol.
It is a colorless or yellowish liquid with a special fragrance. It has a low boiling point and melting point at normal temperature, and is soluble in water and organic solvents such as ethyl ether and alcohols.
The compound has a wide range of applications in organic synthesis. It can be used as a chiral inducer or a starting material of chiral catalyst to synthesize chiral compounds with biological activity. In addition, it can also be used in the preparation of liquid crystals, dyes, pharmaceuticals and pesticides.
The preparation methods of (R)-( )-3-chloro-1-phenyl-1-propanol are diversified. One commonly used method is synthesis by reaction with p-bromotoluene. First, (R)-( )-phenylpropanone is reacted with magnesium bromide to obtain (R)-( )-phenyl-2-propanol, and then the target compound is prepared by Grignard reaction with stannous chloride.
Regarding safety information, the compound should be used and stored in accordance with the appropriate safety procedures. It is a flammable liquid and should be kept away from fire and high temperatures, avoiding contact with oxidants and strong acids. At the same time, care should be taken to avoid inhaling its vapor or contact with skin and eyes. If accidentally contacted, rinse immediately with plenty of water and seek medical help.
It is a colorless or yellowish liquid with a special fragrance. It has a low boiling point and melting point at normal temperature, and is soluble in water and organic solvents such as ethyl ether and alcohols.
The compound has a wide range of applications in organic synthesis. It can be used as a chiral inducer or a starting material of chiral catalyst to synthesize chiral compounds with biological activity. In addition, it can also be used in the preparation of liquid crystals, dyes, pharmaceuticals and pesticides.
The preparation methods of (R)-( )-3-chloro-1-phenyl-1-propanol are diversified. One commonly used method is synthesis by reaction with p-bromotoluene. First, (R)-( )-phenylpropanone is reacted with magnesium bromide to obtain (R)-( )-phenyl-2-propanol, and then the target compound is prepared by Grignard reaction with stannous chloride.
Regarding safety information, the compound should be used and stored in accordance with the appropriate safety procedures. It is a flammable liquid and should be kept away from fire and high temperatures, avoiding contact with oxidants and strong acids. At the same time, care should be taken to avoid inhaling its vapor or contact with skin and eyes. If accidentally contacted, rinse immediately with plenty of water and seek medical help.
Last Update：2024-04-09 20:02:46
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View History
Dapoxetine hydrochloride Impurity M
5-Bromo-2-Ethynylpyridine
BOC-L-6-HYDROXYNORLEUCINE
2-Amino-5-fluoropyridine
5-Bromo-2-Ethynylpyridine
BOC-L-6-HYDROXYNORLEUCINE
2-Amino-5-fluoropyridine